The Self and its Brain 

by Karl R. Popper and John C. Eccles
(Routledge, 1977) 

This work is perhaps the most complete, scientifically leading-edge testimonial to the hypothesis that an incorporeal soul exists.

Popper declares without reservation that he believes "in the ghost in the machine" [3, ch. P4, sec. 30]. That is a popular expression used by neurologists and others who have concluded from observations of the activity of the brain that the brain appears to be receiving instructions from the incorporeal mind or from what Popper and Eccles call the self-conscious self, or what can also be called the soul. Further on Popper says, "The analogy between the brain and computer may be admitted; and it may be pointed out that the computer is helpless without the programmer." [3, ch. P4, sec. 33]. By the programmer Popper means the self-conscious self, which can also be the soul. In concluding the section on the relationship between the brain and the self (i.e. the soul), Popper states:

I have called this section "The Self and Its Brain", because I intend here to suggest that the brain is owned by the self, rather than the other way around. The self is almost always active. The activity of selves is, I suggest, the only genuine activity we know. The active, psycho-physical self is the active programmer of the brain (which is the computer), it is the executant whose instrument is the brain. The mind is, as Plato said, the pilot. It is not, as David Hume and William James suggested, the sum total, or the bundle, or the stream of its experiences: this suggests passivity. It is, I suppose, a view that results from passively trying to observe oneself, instead of thinking back and reviewing one's past actions.

I suggest that these considerations show that the self is not a "pure ego" ... that is, a mere subject. Rather, it is incredibly rich. Like a pilot, it observes and takes action at the same time. It is acting and suffering, recalling the past and planning and programming the future; expecting and disposing. It contains, in quick succession, or all at once, wishes, plans, hopes, decisions to act, and a vivid consciousness of being an acting self, a centre of action. And it owes its selfhood largely to interaction with other persons, other selves, and with World 3. And all this closely interacts with the tremendous "activity" going on in the brain. [3, ch. P4, sec. 33] I wanted to stress this pre-eminence of the self-conscious mind because now I raise the questions: What is the self-conscious mind? How does it come to exist? How is it attached to the brain in all its intimate relationships of give and take? How does it come to be? And in the end, not only how does it come to be, but what is its ultimate fate when, in due course, the brain disintegrates? [3, Dialogue XI]

Sir John Carew Eccles was an Australian neurophysiologist who won the 1963 Nobel Prize in Physiology or Medicine for his work on the synapse.

Sir Karl Raimund Popper, philosopher and a professor at the London School of Economics. He is widely regarded as one of the greatest philosophers of science of the 20th century; he also wrote extensively on social and political philosophy. 

The Self and its Brain: An Argument for Interactionism